IASST Develops Optical Sensing Platform for Early Cholesterol Detection
The device, meant for point-of-care use, offers a low-cost, eco-friendly method to detect cholesterol-linked disorders like heart disease and atherosclerosis early.
A research team from the Institute of Advanced Study in Science and Technology (IASST), Guwahati, has developed a new optical sensing platform to detect cholesterol levels.
The device, designed for point-of-care (POC) applications, offers a cost-effective and environmentally sustainable option for early diagnosis of cholesterol-related disorders, including cardiovascular diseases and atherosclerosis.
The interdisciplinary team, comprising Prof. Neelotpal Sen Sarma, Dr. Asis Bala, and Nasrin Sultana, developed the platform using silk fiber functionalized with phosphorene quantum dots. The sensor is embedded in a cellulose nitrate membrane, forming an electrical sensing interface that eliminates electronic waste.
Sharing insights, Prof. Neelotpal Sen Sarma, one of the lead researchers, said, “Our approach integrates silk fiber within a cellulose nitrate membrane to create an efficient electrical sensing platform. The system is free of electronic waste and supports eco-conscious diagnostic development.”
Validated Across Multiple Biological Samples
The optical sensor has demonstrated high sensitivity and selectivity when tested with various biological samples, including human blood serum, experimental rat blood serum, and milk. These tests show that the device maintains accuracy across different media, making it suitable for both clinical and research applications.
The research findings have undergone peer review and have been published in the journal Nanoscale, which is affiliated with the Royal Society of Chemistry, thus validating the team's claims scientifically.
Moreover, the development of this device addresses the growing need for accessible tools to monitor cholesterol. Cholesterol is essential for several physiological functions, but imbalances can pose significant health risks. Elevated levels of low-density lipoprotein (LDL), often referred to as 'bad' cholesterol, can lead to the formation of arterial plaque. Conversely, insufficient levels of high-density lipoprotein (HDL) can hinder the body’s ability to remove excess cholesterol.
With no dependency on electronic components, the system offers a sustainable alternative to conventional diagnostic devices.
While clinical deployment would require further regulatory approval and scaling, the technology represents a step forward in healthcare diagnostics.
